dominant negative

The data indicated that the mutation of LIF did not have a dominant negative effect but lost the biological functions, suggesting that the 29th amino acid is critical for maintaining the activities of LIF.

而29位氨基酸突变的LIF因子则完全丧失了以上功能，但所发现的突变没有显性负的作用.结果充分说明，LIF中高度保守的29位氨基酸对LIF功能的维持具有重要的作用。

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The inhibitory effects on hepatitis B virus replication by transient ex-pression of dominant negative mutants of hepatitis B virus X gene

HBX-GFP基因工程DN突变体瞬时表达及乙型肝炎病毒复制的实验研究

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The results of dominant lethal test showed no statistical difference in the number of living, dead and resorbed fetuses between the exposed and the negative control groups.

显性致死实验结果表明各剂量组的受孕率、死胎和吸收胎数经统计学处理与阴性对照组无差异。

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Conclusion data identify the dominant-negative allele ALK 2 L 343 P in a patient with AVS defects.

结论—这些实验结果证实了显性抑制的ALK2变异体-L343P等位基因存在于房室间隔缺损患者中.

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Objective: In this study, the prokaryotic expression plasmids of fusion protein of protein A-PKC ε catalytic domain ( wild type and dominant negative type) are respectively constructed. The fusion proteins are expressed in E.

[目的]构建原核蛋白A高表达载体pPA，进而构建重组质粒pPA-FLC和pPA-ANC，在大肠杆菌中表达蛋白A-PKCε催化功能域融合蛋白并纯化、鉴定。

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The frequency of positive and negative alleles, and the proportion of dominant and recessive alleles in the parents for culm length and its CRI were equal.

亲本中控制秆长及其CRI值的正、负等位基因的频率基本相等，显隐性基因频率基本相同；

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Gram-negative bacteria were the dominant culturable bacteria of shrimp intestinal microflora of two ponds.

2个虾池对虾肠道微生物群落可培养细菌优势菌属都是革兰氏阴性菌；

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The study of interfering on HBV particle assembly in S gene dominant negative mutant

S基因显性阴性突变体干扰乙肝病毒颗粒组装的研究

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Objective To explore the possibility of using HBV as a gene delivery vector, and to test the anti-HBV effects by intracellular expression of dominant negative mutants of core protein.

目的探索HBV作为基因治疗载体的可能性及检验HBV点突变表达显性阴性突变体抗HBV的作用。

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Study of Signal Transduction Mediated by Integrin α IIb β 3 Using a Dominant Negative Model

利用显性阴性模型对整合素αIIbβ3介导的信号转导的初步研究

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The results indicate that: ① The overall association among 12 dominant populations is significantly negative, which is closely connected with the present successional state of the community and environmental instability caused by disturbance.

结果表明：①12个优势种群在总体上呈显著的负联结，这跟该群落目前所处的演替状态及干扰造成的环境不稳定有密切的关系。

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A Study on Anti-wt-HBV Dominant Negative Mutants Constructed by Interfering Mutation in Replication

利用复制干扰突变构建具有抗HBV作用的显性阴性突变体研究

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AIM: To investigate the inhibitory effect on hepatitis B virus ( HBV) replication with dominant negative ( DN) mutant of VP22 fusion protein.

目的了解VP22融合型显性负性（DN）突变体对抑制乙肝病毒（HBV）复制的作用。

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The dominant negative inhibitors discussed earlier as possible treatments could be useful forms of protective antigen to choose.

而前面讨论过的具医疗可行性的显性无效抑制因子，则可以选做有用的保护性抗原。

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The dominant index is in negative correlation to diversity index. Ambient concentrations varied considerably by season.

优势集中性指数与多样性指数呈负相关变化。环境浓度随季节而大幅度变化。

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Conclusion Dominant negative mutants of core protein can efficiently suppress wt-HBV replication and the expressions of HBV antigens.

结论在细胞内表达显性阴性突变体具有干扰HBV复制及抑制HBV抗原表达的作用；

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Survivin protein mutant Survivin ( T34A), is a dominant negative mutant of Survivin protein. It can reverse the role of Survivin of the anti-apoptotic, promote the death of cancer cells.

Survivin蛋白突变体Survivin（T34A）是Survivin蛋白的显性负性突变体，它能够逆转Survivin的抗凋亡作用，促进癌细胞死亡。

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Anti-HBV effects of genetically engineered replication-defective HBV with combined expression of antisense RNA and dominant negative mutants of core protein and construction of first-generation packaging cell line for HBV vector

基因重组HBV联合表达反义RNA和显性阴性突变体抗HBV作用及HBV包装细胞系的构建

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Elimination of the Integrin α 6 β 1 Laminin Receptor on Human Hepatocellular Carcinoma Cell Surface by a Dominant Negative Strategy

以dominant negatiVe策略消除人肝癌细胞表面层粘连蛋白受体α6β1的功能

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Blocking the JNK pathway by transfection of a dominant negative form of JNK ( JNK APF) brought about significant inhibition of cell death induced by serum depletion with an inhibiting rate as high as 15%.

用JNK无活性突变体转染阻断JNK通路，对血清撤离引起的细胞死亡有明显抑制作用，抑制率达15%。

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Study on anti-HBV effects of genetically engineered replication-defective hepatitis B virus expressing dominant negative mutants of core protein

复制缺损型HBV表达显性阴性突变体抗HBV作用的研究

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Among which 70 were Gram-negative bacteria ( GNB) and 9 were Gram-positive bacteria. The dominant bacterium was Pseudomonas aeruginosa in patients with VAP.

其中革兰阴性杆菌70株，革兰阳性球菌9株，VAP居首位的细菌是铜绿假单胞菌。

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RESULTS The rate of nosocomial infection in elderly patients with pulmonary tuberculosis is 28.1%, the main infection way is via respiration, and the dominant pathogens are Gram negative bacteria.

结果老年肺结核病患者医院感染率为28.1%，感染部位以呼吸道为主，泌尿道、肠道次之；

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Dominant both Classroom and Negative Classroom, Training Students' English Listening and Speaking Ability

显性课堂和隐性课堂并重培养学生英语听说能力

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Objective To investigate the effect on assembly of HBV particle in S gene dominant negative mutant.

目的探讨S基因突变对HBV病毒颗粒组装的影响。

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The dominant negative mutant of JNK was used to explore if the blocking of the JNK pathway led to cell death inhibition.

使用负显性（dominant negatiVe）JNK突变体转染293细胞，来探讨阻断JNK通路对细胞死亡的抑制作用。

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